Congratulations to Prof. Rami Aqeilan and Osama Hidmi on their newly published review in Trends in Genetics: “Breaking the script: transcriptional addiction as a driver of genome instability in cancer”

In this article, the authors synthesize recent advances showing that the “transcriptional addiction” many cancers rely on is also a major source of endogenous DNA damage. They highlight a key conceptual distinction between replication-dependent transcription breaks (such as transcription–replication conflicts) and replication-independent breaks that arise directly from transcription itself. The review also proposes a useful […]

Congratulations to Prof. Rami Aqeilan and Osama Hidmi on their new research article published in Science Advances

In this study, the team maps genome-wide DNA double-strand breaks (DSBs) linked to transcription stress in cancer using sBLISS together with transcription-stress markers. They show that superenhancers shape where transcription stress concentrates in the genome, revealing a regulatory logic to these damage “hotspots.”  Notably, while γH2AX is enriched at many transcription-stress sites, DSB-rich genes differ […]

Congratulations to Prof. Rami Aqeilan, Prof. Yotam Drier and Sara Oster Flayshman on their recent publication in the journal Cell Death & Disease!

Researchers from the Aqeilan Lab, in collaboration with the Drier Lab at the Lautenberg Center for Immunology and Cancer Research, have uncovered new insights into how inherited BRCA1 and BRCA2 mutations initiate cancer development long before tumors form. In a study published in Cell Death & Disease, the team mapped DNA double-strand breaks across the genome […]

Farewell to Our Graduates

Last Wednesday, we gathered in the kitchen to say goodbye to our graduates: Sara Oster and Tirtza Bidani from Prof. Rami Aqeilan’s lab, and Erik Hung from Yinon Ben Neriah’s lab, as they completed their PhD studies with us. It was a relaxed and lovely gathering, and we’re happy to share a few photos from […]

The Lautenberg Center Says Goodbye to Our Amazing Administrative Manager, Moriah Sapir

The Lautenberg Center came together to say goodbye to Moriah Sapir, our amazing administrative manager. Moriah took care of every detail in the center with dedication, warmth, and endless professionalism — always looking out for every PI and every student. She led countless initiatives, including building and driving the Lautenberg website, organizing unforgettable retreats, and […]

Happy New Year from the Lautenberg Center

In honor of Rosh Hashana, the department gathered for a celebratory toast to welcome the new year together.We send heartfelt wishes for a happy, healthy, and peaceful year to all. This year’s celebration was significant as we marked the 90th birthday of Prof. Chaim Brautbar, honoring his extraordinary contributions to science, medicine, and generations of […]

Congratulations to Dr. Oded Shamriz, Zahala Bar-On, Or Reuven, Prof. Michael Berger, and Prof. Michal Baniyash on their recent publication in the Journal of Clinical Immunology!

The Lautenberg Center for Immunology and Cancer Research proudly congratulates Dr. Oded Shamriz, Zahala Bar-On, Or Reuven, Prof. Michael Berger, and Prof. Michal Baniyash on the publication of their groundbreaking study, titled “β-Actin Deficiency in Baraitser-Winter Syndrome Type 1 Disrupts T-Cell Function and Immune Regulation: Implications for Targeted Therapy in Actinopathies”, in the Journal of […]