The researchers revealed how SARS-CoV-2 infection perturbs enhancer-mediated regulation in lung alveolar cells to drive key pathways that support disease progression, including Wnt signaling, MAPK signaling and cell adhesion. In particular, they focus on the transcription factor WT1 and show its disruption by SARS-CoV-2 plays an important role in these perturbed transcriptional networks.
To Dr. Drier lab page
To the paper
