In the paper, the researchers profile single cells of adenoid cystic carcinoma tumors, and reveal the transcriptional characteristics of two malignant cell types – myoepithelial cells and luminal epithelial cells. Computational analysis reveals paracrine interactions between the myoepithelial cells that express Notch ligands DLL1, JAG1, and JAG2 which activate the Notch pathway in the luminal cells, supporting their oncogenic growth.
Figure 2D: Heatmap shows expression of the top 200 genes in each of the four NMF programs detected in an individual representative sample. Key genes are annotated on the left, and inferred cell identity is shown on the top.
