In their research, Prof. Berger and Dr. Saragovi used a unique mouse model to examine T-Cell antiviral responses in mice which were kept under low oxygen conditions.
Using molecular, pharmacological, and genetic methods they showed that T-Cell failure to respond under hypoxia stems from mitochondrial biogenesis arrest.
They then demonstrated that hypoxia-arrested T cells in-vivo could be rescued by short exposure to atmospheric oxygen conditions.
Their findings allow for a better understanding of viral infections in hypoxia-associated diseases, and may have clinical implications in the future treatment of such infections.
To the paper
To Prof. Berger lab
