In the article, they found that Natural Killer (NK) cells play a role in the immune response against Candida albicans, a common fungal pathogen and a prevalent cause of deadly bloodstream infections. They also found that the fungal cells can inhibit NK cells and that by blocking the NK-fungi inhibitory interaction, using immunotherapy with a TIGIT-blocking antibody, they can re-establish anti-Candida immunity. This discovery can hopefully serve as a potential therapeutic tool in the future.
Figure 2.C. albicans binding of TIGIT is functional and leads to inhibition of NK and T cells.