Prof. Michael Berger  

Phone:  +97226757103


Eat, drink, breathe T cells

T cells constitute a pivotal component of our adaptive immune system, playing a dominant role in the immune response against viruses and cancer. The metabolic programs governing T cell function are of exceptional significance, dictating their behaviors and determining functional outcomes. Thus, unraveling the intricacies of T cell metabolic adaptations in specific contexts assumes critical importance. Such insights are integral to comprehending the mechanisms underlying immune defense against pathogens and malignancies, all while preserving tissue homeostasis.

Our research endeavors are centered around three fundamental domains:

  1. Deciphering T Cell Metabolic Demands: We strive to elucidate the precise metabolic requisites that govern T cell functionality. This involves unraveling the intricate network of metabolic pathways that fuel these cells under diverse conditions.
  2. Metabolic Pathways and T Cell Differentiation/Function: We are dedicated to investigating the profound impact of metabolic pathways on the differentiation and functional attributes of T cells. This pursuit involves unraveling the interplay between metabolic cues and T cell fate decisions.
  3. Translating Insights into Innovative Medical Technologies: We are committed to harnessing the knowledge gleaned from our investigations to catalyze the development of novel medical technologies. Our aim is to exploit these findings for the advancement of therapeutic interventions.

In recent years, our research activities have yielded substantial breakthroughs across these domains. We have unveiled the critical role of processes such as mitochondrial biogenesis and water metabolism in governing the functionality of T cells. Additionally, we have probed into the responses of T cells in the context of metabolic disorders, revealing compromised immune responses in affected individuals. Notably, we have pioneered an innovative technology designed to augment the efficacy of adoptive T cell transfer therapy, particularly in the treatment of solid tumors.

Collectively, our research thrusts not only enhance our fundamental understanding of T cell metabolism but also hold the promise of translating these insights into tangible advancements in medical science. This could ultimately revolutionize therapeutic approaches and bolster our arsenal against challenging diseases.

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